Selective 5HT2A and 5HT6 Receptor Antagonists Promote Sleep in Rats
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چکیده
منابع مشابه
[Selective muscarinic receptor antagonists].
3ubtypes of muscarmic receptors, first hypothesized by Birdsall et al. ~ to explain the anomalous binding of cholinergic agonists to brain receptors~ were later demonstrated with the seEective muscarinic antagonist, pirenzepine 2. Interestingly, the search for selective antagonists, which usually follows the acceptance of a concept, antedated by many years the notion of heterogeneity of rmecari...
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To develop compounds that are antagonists on ER , but not ER , we have added basic side-chains typically found in nonsteroidal antiestrogens to pyrazole compounds that bind with much higher affinity to ER than to ER . In this way we have developed basic side-chain pyrazoles (BSC-pyrazoles) that are high affinity, potent, selective antagonists on ER . These BSCpyrazoles are themselves inactive o...
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ژورنال
عنوان ژورنال: Sleep
سال: 2008
ISSN: 1550-9109,0161-8105
DOI: 10.1093/sleep/31.1.34